KMID : 1123920100240010055
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Korean Journal of Oriental Physiology and Pathology 2010 Volume.24 No. 1 p.55 ~ p.60
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Caesalpinia sappan L. Induces G2/M Phase Cell Cycle Arrest in Human Lymphoma U937 Cells
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Jeon Byung-Jae
Ju Sung-Min Yang Hyun-Mo Kim Bo-Hyun Kim Won-Sin Jeon Byung-Hoon
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Abstract
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Caesalpinia sappan L. (C. sappan) has long been used in traditional medicine as an emmenagogue, hemostatic and anti-inflammatory agent. The present study investigated the effects of water extract of C. sappan in human lymphoma U937 cells. The proliferation of U937 cells was decreased by C. sappan in a dose-dependently manner. Anti-proliferative effect of C. sappan on U937 cells was associated with G2/M phase arrest, which was mediated by regulating the expression of p21 protein. Moreover, phosphorylation of JNK and p38 was increased by C. sappan. Blockade of JNK and p38 was significantly inhibited C. sappan-induced G2/M phase arrest. Taken together, these results suggest that Anti-proliferative effect of C. sappan on U937 is assocated with G2/M phase cell cycle arrest by expression of p21 protein and, JNK and p38 activation.
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KEYWORD
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Caesalpinia sappan L., U937 cells, Cell cycle arrest, G2/M phase, p21, JNK, p38
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